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High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3,   Pages 376-380 doi: 10.1007/s11705-015-1531-5

Abstract: The Chinese Hamster Ovary (CHO K1) cell was used to express a targeted anti-cancer monoclonal antibodyThe adherent CHO K1 was first adapted to suspension culture in chemical defined medium.The best cell pool of CHO K1/IgG1 was used to screen the top single clone using the limiting dilution

Keywords： Chinese hamster ovary (CHO)     monoclonal antibody     IgG1     amplification     cell line development    

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Polycystic ovary syndrome

Zi-Jiang CHEN, Yuhua SHI

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 280-284 doi: 10.1007/s11684-010-0098-2

Abstract: Polycystic ovary syndrome (PCOS) is a common gynecologic endocrinopathy.

Keywords： polycystic ovary syndrome     genetics     metabolic disturbance    

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Hospital-Based Phenotypic Features and Treatment Outcomes of Chinese Women with Polycystic Ovary Syndrome Article

Jingshu Gao, Hongli Ma, Yu Wang, Xinming Yang, Yijuan Cao, Bei Zhang, Conghui Han, Xiaoke Wu

Engineering 2021, Volume 7, Issue 2,   Pages 170-177 doi: 10.1016/j.eng.2020.12.006

Abstract:

Genetic, lifestyle, and environmental factors contribute to the etiology of polycystic ovary syndromesecondary analysis of a large-sample, multicenter, randomized controlled trial conducted at 21 sites in Chinese

Keywords： Polycystic ovary syndrome     Body mass index     Phenotype     Chinese cohort     Geographic distribution    

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Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4,   Pages 399-406 doi: 10.1007/s11705-009-0253-y

Abstract: -Carrageenan and -lactoglobulin (-lg) stabilized oil-in-water (O/W) emulsions, which can be used for the oral administration of bioactive but environmentally sensitive ingredients, have been successfully prepared. The effects of protein/polysaccharide ratios, total biopolymer concentration, environmental stress (thermal processing and sonication), and pH on the complex formation between -carrageenan and -lactoglobulin have been investigated. We found that -lactoglobulin and-carrageenan stabilized emulsions can be formed at pH values of 6.0, 4.0, and 3.4. However, the microstructures of emulsions stabilized by -lactoglobulin and -carrageenan was identified by optical microscopy, and it indicated that the emulsion prepared at pH 6.0 flocculated more extensively, while its hydrodynamic radius was much bigger than those prepared at pH 4.0 and 3.4. Regarding rheological properties, the emulsion of pH 6.0 showed a more solid-like behavior but with a lower viscosity than those of pH 4.0 and 3.4. The optimum concentration ranges for -lg and-carrageenan to form stable emulsions at pH 4.0 and 3.4 were 0.3wt-%―0.6wt-% and 0.4wt-%―0.7wt-%, respectively.
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Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with

Bo Huang, Zhou Li, Xinling Ren, Jihui Ai, Lixia Zhu, Lei Jin

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 247-252 doi: 10.1007/s11684-017-0519-6

Abstract:

The activity of free radicals in follicular fluid was related to ovarian responsiveness, in vitro fertilization (IVF), and embryo transfer success rate. However, studies analyzing the relationship between the free radical scavenging capacity and embryo quality of infertile women with polycystic ovarian syndrome (PCOS) were lacking. The aim of this study was to evaluate the relationship between the free radical scavenging window of women with PCOS and their embryo quality. The free radical scavenging capacity of follicular fluid from women with PCOS was determined by a,a-diphenyl-b-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethylbenzthiazoline-6-sulphonic acid) assay, superoxide radical, and reactive oxygen species (ROS) assay. In the DPPH and ROS assays, the follicular fluid from grades I and II embryos was significantly higher than the follicular fluid from grades III and IV embryos. The lower control limit of DPPH radical scavenging capacity and upper control limit of ROS level were 13.2% and 109.0 cps, respectively. The calculated lower control limit and upper control limit were further confirmed in the follicular fluid of embryos of all grades. These cut-off values of free radical scavenging activity of follicular fluid could assist embryologists in choosing the development of embryos in PCOS patients undergoing IVF.

Keywords： in vitro fertilization     PCOS     free radical     embryo quality    

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Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Frontiers in Energy 2009, Volume 3, Issue 4,   Pages 414-422 doi: 10.1007/s11708-009-0038-5

Abstract: An axial-type fan that operates at a relative total pressure of 671Pa and a static pressure of 560Pa with a flowrate of 416.6m/min is developed using an optimization technique based on the gradient method. Prior to the optimization of the fan blade, a three-dimensional axial-type fan blade is designed based on the free-vortex method along the radial direction. Twelve design variables are applied to the optimization of the rotor blade, and one design variable is selected for optimizing a stator which is located behind the rotor to support a fan-driving motor. The total and static pressure are applied to the restriction condition with the operating flowrate on the design point, and the efficiency is chosen as the response variable to be maximized. Through these procedures, an initial axial-fan blade designed by the free vortex method is modified to increase the efficiency with a satisfactory operating condition. The optimized fan is tested and compared with the performance obtained with the same class fan to figure out the optimization effect. The test results show that the optimized fan not only satisfies the restriction conditions but also operates at the same efficiency even though the tip clearance of the optimized fan is greater than 30%. The experimental and numerical tests show that this optimization method can improve the efficiency and operating pressures on axial-type fans.

Keywords： axial-type fan     gradient method     free-vortex method     design variable     total pressure     static pressure     operating flowrate    

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Preliminary experimental study of a supercritical CO

Junhyun CHO, Hyungki SHIN, Jongjae CHO, Young-Seok KANG, Ho-Sang RA, Chulwoo ROH, Beomjoon LEE, Gilbong

Frontiers in Energy 2017, Volume 11, Issue 4,   Pages 452-460 doi: 10.1007/s11708-017-0504-4

Abstract: Research on applying a supercritical carbon dioxide power cycle (S-CO ) to concentrating solar power (CSP) instead of a steam Rankine cycle or an air Brayton cycle has been recently conducted. An S-CO system is suitable for CSP owing to its compactness, higher efficiency, and dry-cooling capability. At the Korea Institute of Energy Research (KIER), to implement an S-CO system, a 10 kWe class test loop with a turbine-alternator-compressor (TAC) using gas foil bearings was developed. A basic sub-kWe class test loop with a high-speed radial type turbo-generator and a test loop with a capability of tens of kWe with an axial type turbo-generator were then developed. To solve the technical bottleneck of S-CO turbomachinery, a partial admission nozzle and oil-lubrication bearings were used in the turbo-generators. To experience the closed-power cycle and develop an operational strategy of S-CO operated at high pressure, an organic Rankine cycle (ORC) operating test using a refrigerant as the working fluid was conducted owing to its operational capability at relatively low-pressure conditions of approximately 30 to 40 bar. By operating the sub-kWe class test loop using R134a as the working fluid instead of CO , an average turbine power of 400 W was obtained.

Keywords： supercritical CO2     power cycle     turbomachinery     compressor     turbine    

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Insight into the role of cholesterol in modulation of morphology and mechanical properties of CHO-K1

Lei Zhang, Lisha Zhao, Ping-Kai Ouyang, Pu Chen

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 1,   Pages 98-107 doi: 10.1007/s11705-018-1775-y

Abstract: In this study, the effects of cholesterol on the topography and mechanical behaviors of CHO-K1 cells

Keywords： cholesterol     methyl-β-cyclodextrin     atomic force microscopy     Young’s modulus     CHO-K1 cell    

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Effects of a dynamic membrane formed with polyethylene glycol on the ultrafiltration of natural organic matter

Boksoon KWON, Noeon PARK, Jaeweon CHO,

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 2,   Pages 172-182 doi: 10.1007/s11783-010-0002-y

Abstract: The formation of a dynamic membrane (DM) was investigated using polyethylene glycol (PEG) (molecular weight of 35000 g/mol, concentration of 1 g/L). Two natural organic matters (NOM), Dongbok Lake NOM (DLNOM) and Suwannee River NOM (SRNOM) were used in the ultrafiltration experiments along with PEG. To evaluate the effects of the DM with PEG on ultrafiltration, various transport experiments were conducted, and the analyses of the NOM in the membrane feed and permeate were performed using high performance size exclusion chromatography, and the pore size distribution ( PSD) and molecular weight cut off ( MWCO) were determined. The advantages of DM formed with PEG can be summarized as follows: (1) PEG interferes with NOM transmission through the ultrafiltration membrane pores by increasing the retention coefficient of NOM in UF membranes, and (2) low removal of NOM by the DM is affected by external factors, such as pressure increases during UF membrane filtration, which decreases the PSD and MWCO of UF membranes. However, a disadvantage of the DM with PEG was severe flux decline; thus, one must be mindful of both the positive and negative influences of the DM when optimizing the UF performance of the membrane.

Keywords： dynamic membrane     natural organic matters     ultrafiltration membrane performance     effective PSD     effective molecular weight cutoff    

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New Monitoring Technologies for Overhead Contact Line at 400 km·h−1

Chul Jin Cho, Young Park

Engineering 2016, Volume 2, Issue 3,   Pages 360-365 doi: 10.1016/J.ENG.2016.03.016

Abstract:

Various technologies have recently been developed for high-speed railways, in order to boost commercial speeds from 300 km·h−1to 400 km·h−1. Among these technologies, this paper introduces the 400 km·h−1 class current collection performance evaluation methods that have been developed and demonstrated by Korea. Specifically, this paper reports details of the video-based monitoring techniques that have been adopted to inspect the stability of overhead contact line (OCL) components at 400 km·h−1 without direct contact with any components of the power supply system. Unlike conventional OCL monitoring systems, which detect contact wire positions using either laser sensors or line cameras, the developed system measures parameters in the active state by video data. According to experimental results that were obtained at a field-test site established at a commercial line, it is claimed that the proposed measurement system is capable of effectively measuring OCL parameters.

Keywords： High-speed railway     Overhead contact lines     Condition monitoring     Image processing based measurement    

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in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary

Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 518-524 doi: 10.1007/s11684-017-0575-y

Abstract: oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary

Keywords： PCOS     ROS     granulosa cell     IVF-ET     NADPH oxidase    

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Interfacial heat transfer coefficient between metal and die during high pressure die casting process of aluminum alloy

GUO Zhipeng, XIONG Shoumei, CHO SangHyun, CHOI JeongKil

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 3,   Pages 283-287 doi: 10.1007/s11465-007-0049-z

Abstract: The present work focused on the determination of the interfacial heat transfer coefficient (IHTC) between metal and die during the high pressure die casting (HPDC) process. Experiments were carried out on an aluminum alloy, ADC12Z, using step shape casting so-called because of its shape. The IHTC was successfully determined by solving one of the inverse heat problems using the nonlinear estimation method first used by Beck. The calculation results indicated that the IHTC immediately increased after liquid metal was brought into the cavity by the plunger and decreased as the solidification process of the liquid metal proceeded. The liquid metal eventually solidified completely, a condition when the IHTC tended to be stable. Casting thickness played an important role in affecting the IHTC between the metal and die not only in terms of its value but also in terms of its change tendency. Also, under the test conditions, different change tendencies of the metal solid fraction were found between castings with different thicknesses and the die.

Keywords： so-called     calculation     inverse     interfacial     aluminum    

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The study of ovary development and steroid hormone changes in Alosa sapidissima

Hong Lei,Li Zhaoxin,Chen Chao,Guo Zhenglong,Wang Weifang,Lei Jilin

Strategic Study of CAE 2014, Volume 16, Issue 9,   Pages 86-92

Abstract:

In this study, the morphological changes of ovary development and variationnon-synchronized multiple batch spawner; based on size, shape and external color, the development of ovaryestradiol (E2) were found to increase during the peak phase of vitellogenic growth corresponding to the ovary

Keywords： Alosa sapidissima     ovary development     oogenesis     histology     morphology     steroid hormone    

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Development of an integrated modeling system for improved multi-objective reservoir operation

Lei WANG, Cho Thanda NYUNT, Toshio KOIKE, Oliver SAAVEDRA, Lan Chau NGUYEN, Tran van SAP,

Frontiers of Structural and Civil Engineering 2010, Volume 4, Issue 1,   Pages 47-55 doi: 10.1007/s11709-010-0001-x

Abstract: Reservoir is an efficient way for flood control and improving all sectors related to water resources in the integrated water resources management. Moreover, multi-objective reservoir plays a significant role in the development of a country’s economy especially in developing countries. All multi-objective reservoirs have conflicts and disputes in flood control and water use, which makes the operator a great challenge in the decision of reservoir operation. For improved multi-objective reservoir operation, an integrated modeling system has been developed by incorporating a global optimization system (SCE-UA) into a distributed biosphere hydrological model (WEB-DHM) coupled with the reservoir routing module. The new integrated modeling system has been tested in the Da River subbasin of the Red River and showed the capability of reproducing observed reservoir inflows and optimizing the multi-objective reservoir operation. First, the WEB-DHM was calibrated for the inflows to the Hoa Binh Reservoir in the Da River. Second, the WEB-DHM coupled with the reservoir routing module was tested by simulating the reservoir water level, when using the observed dam outflows as the reservoir release. Third, the new integrated modeling system was evaluated by optimizing the operation rule of the Hoa Binh Reservoir from 1 June to 28 July 2006, which covered the annual largest flood peak. By using the optimal rule for the reservoir operation, the annual largest flood peak at downstream control point (Ben Ngoc station) was successfully reduced (by about 2.4m for water level and 2500m·s for discharge); while after the simulation periods, the reservoir water level was increased by about 20m that could supply future water use.

Keywords： distributed biosphere hydrological model (WEB-DHM)     optimization     multi-objective reservoir     the Red River basin    

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Effects of heavy rainfall on the composition of airborne bacterial communities

Gwang Il Jang, Chung Yeon Hwang, Byung Cheol Cho

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 2, doi: 10.1007/s11783-018-1008-0

Abstract: Wet deposition scavenges particles and particle-associated bacteria from the air column, but the impact of raindrops on various surfaces on Earth causes emission of surface-associated bacteria into the air column. Thus, after rainfall, these two mechanisms are expected to cause changes in airborne bacterial community composition (BCC). In this study, aerosol samples were collected at a suburban site in Seoul, Korea before and after three heavy rainfall events in April, May, and July 2011. BCC was investigated by pyrosequencing the 16S rRNA gene in aerosol samples. Interestingly, the relative abundance of non-spore forming operational taxonomic units (OTUs) was always higher in post-rain aerosol samples. In particular, the absolute and relative abundances of airborne always increased after rainfall, whereas those of airborne , including and , consistently decreased. Marine bacterial sequences, which were temporally important in aerosol samples, also decreased after rainfall events. Further, increases in pathogen-like sequences were often observed in post-rain air samples. Rainfall events seemed to affect airborne BCCs by the combined action of the two mechanisms, with potentially adverse effects on human and plant health.

Keywords： Aerosol     Bacteria     Community composition     Pyrosequencing     Rain    

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Title Author Date Type Operation

High-level expression of recombinant IgG1 by CHO K1 platform

Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu

Journal Article

Polycystic ovary syndrome

Zi-Jiang CHEN, Yuhua SHI

Journal Article

Hospital-Based Phenotypic Features and Treatment Outcomes of Chinese Women with Polycystic Ovary Syndrome

Jingshu Gao, Hongli Ma, Yu Wang, Xinming Yang, Yijuan Cao, Bei Zhang, Conghui Han, Xiaoke Wu

Journal Article

Biopolymer-stabilized emulsions on the basis of interactions between β -lactoglobulin and ι -carrageenan

Qiaomei RU, Younghee CHO, Qingrong HUANG,

Journal Article

Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with

Bo Huang, Zhou Li, Xinling Ren, Jihui Ai, Lixia Zhu, Lei Jin

Journal Article

Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Journal Article

Preliminary experimental study of a supercritical CO

Junhyun CHO, Hyungki SHIN, Jongjae CHO, Young-Seok KANG, Ho-Sang RA, Chulwoo ROH, Beomjoon LEE, Gilbong

Journal Article

Insight into the role of cholesterol in modulation of morphology and mechanical properties of CHO-K1

Lei Zhang, Lisha Zhao, Ping-Kai Ouyang, Pu Chen

Journal Article

Effects of a dynamic membrane formed with polyethylene glycol on the ultrafiltration of natural organic matter

Boksoon KWON, Noeon PARK, Jaeweon CHO,

Journal Article

New Monitoring Technologies for Overhead Contact Line at 400 km·h−1

Chul Jin Cho, Young Park

Journal Article

in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary

Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin

Journal Article

Interfacial heat transfer coefficient between metal and die during high pressure die casting process of aluminum alloy

GUO Zhipeng, XIONG Shoumei, CHO SangHyun, CHOI JeongKil

Journal Article

The study of ovary development and steroid hormone changes in Alosa sapidissima

Hong Lei,Li Zhaoxin,Chen Chao,Guo Zhenglong,Wang Weifang,Lei Jilin

Journal Article

Development of an integrated modeling system for improved multi-objective reservoir operation

Lei WANG, Cho Thanda NYUNT, Toshio KOIKE, Oliver SAAVEDRA, Lan Chau NGUYEN, Tran van SAP,

Journal Article

Effects of heavy rainfall on the composition of airborne bacterial communities

Gwang Il Jang, Chung Yeon Hwang, Byung Cheol Cho

Journal Article